BIOGRAPHICAL SKETCH

Biomedical Engineering Department, Engineering Faculty, the University of Isfahan, HezarJerib.st.
Isfahan, IRAN 81746-734

E-mail: m.mehdikhani@eng.ui.ac.ir 

Homepage: http://eng.ui.ac.ir/~m.mehdikhani/

 


Home Phone: +98 (31) 36306519
Cell Phone: +98 9132709816
Work Phone: +98 (31) 37934022

NAME: Mehdikhani, Mehdi

POSITION TITLE: Associate Professor of Biomedical Engineering

EDUCATION/TRAINING

 

INSTITUTION AND LOCATION

DEGREE

(if applicable)

 

Start Date

MM/YYYY

Completion Date

MM/YYYY

 

FIELD OF STUDY

 

Isfahan University of Technology, Isfahan, IRAN

Ph.D.

09/2005

02/2011

Biomaterials

Isfahan University of Technology, Isfahan, IRAN

M.Sc.

09/2001

02/2004

Materials Engineering-Corrosion and Protection of Materials

Islamic Azad University, Najafabad , Isfahan, IRAN

B.S

09/1996

09/2000

Materials Engineering

 

A. Research Interest

 

      My research is focused on ‘Biomaterials for regenerative medicine and their use in drug delivery systems. I am interested in developing biodegradable polymer-based composites for bone, cartilage, skin, heart, nerve, ocular, and gastrointestinal tract tissue engineering. Rational design and development of novel biodegradable polymer scaffolds with customized properties tailored to deliver drugs in a time-dependent manner to induce specific tissue regeneration is my considerable interest. Furthermore, I am working on surface modification of the scaffolds to improve cell interaction and enhanced properties in vivo.  

 

 

B. Positions and Honors

Positions and Employment

2011-2014       Assistant Professor, Department of Materials Engineering, Faculty of Engineering, Semnan University, Semnan, IRAN

2014-2021       Assistant Professor, Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, IRAN.

2021- Ongoing Associate Professor, Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, IRAN.

 

Reviewer in the international journals

 

2014-Present Reviewer in the international journals (Materials Science & Engineering C, Journal of Medical Signals and Sensors, Dental Research Journal, Polymer Testing, Fibers and Polymers, etc.)

 

 

Honors and Awards

2015                Outstanding presentation in the idea festival in improving research at Isfahan University of

                        Medical Sciences

Grants

2012-2017             Iran National Science Foundation

2015-2017            Council for Stem Cell Sciences & Technologies

 

 


C. Contributions to Science


Published ISI papers in the research lines

  1. Shahravi Z, Mehdikhani M, Amirkhani MA, Mollapour Sisakht M, Farsaei S, Multifunctional electrospun polyvinyl alcohol/gellan gum/polycaprolactone nanofibrous membrane containing pentoxifylline to accelerate wound healing, Polymer Bulletin,  https://doi.org/10.1007/s00289-022-04446-1.
  2. Ghaziof S, Shojaei S, Mehdikhani M, Khodaei M, Jafari Nodoushan M, Electro-conductive 3D printed polycaprolactone/gold nanoparticles nanocomposite scaffolds for myocardial tissue engineering, Journal of the Mechanical Behavior of Biomedical Materials, 132; 2022, 105271.
  3. Yousefi P, G. Dini, B Movahedi, Vaezifar S & Mehdikhani M, Polycaprolactone/chitosan core/shell nanofibrous mat fabricated by electrospinning process as carrier for rosuvastatin drug, Polymer Bulletin, 79; 2022:1627–1645.
  4. Rastegar S, Mehdikhani M, Bigham A, Poorazi E, Rafienia M,  Poly glycerol sebacate/ polycaprolactone/ carbon quantum dots fibrous scaffold as a multifunctional platform for cardiac tissue engineering, Materials Chemistry and Physics, 266; 2021: 124543.
  5. Ahmadi M, Mehdikhani M, Varshosaz J, Farsaei S, Torabi H, Pharmaceutical evaluation of atorvastatin-loaded nanostructured lipid carriers incorporated into the gelatin/hyaluronic acid/polycaprolactone scaffold for the skin tissue engineering, Journal of Biomaterials Applications, 35(8); 2021: 958-977.
  6. Yousefi P, Dini G, Movahedi B, Vaezifar S, Mehdikhani M, Polycaprolactone/chitosan core/shell nanofibrous mat fabricated by electrospinning process as carrier for rosuvastatin drug, Polymer Bulletin, 2021, https://doi.org/10.1007/s00289-021-03566-4.
  7. Torabi H, Mehdikhani M, Varshosaz J, Shafiee F, An innovative approach to fabricate a thermosensitive melatonin‐loaded conductive pluronic/chitosan hydrogel for myocardial tissue engineering, Journal of Applied Polymer Science, 18(138); 2021: app50327.
  8. Etemadi N, Mehdikhani M, Poorazizi E, Rafienia M, Novel bilayer electrospun poly(caprolactone)/ silk fibroin/ strontium carbonate fibrous nanocomposite membrane for guided bone regeneration, Journal of Applied Polymer Science, 16(138); 2021: 50264.
  9. Afshar M, Dini G, Vaezifar S, Mehdikhani M, Movahedi B, Preparation and characterization of sodium alginate/polyvinyl alcohol hydrogel containing drug-loaded chitosan nanoparticles as a drug delivery system, Journal of Drug Delivery Science and Technology, 56; Part A; 2020: 101530.
  10. Zargar SM, Mehdikhani M, Rafienia M, Reduced graphene oxide–reinforced gellan gum thermoresponsive hydrogels as a myocardial tissue engineering scaffold, Journal of Bioactive and Compatible Polymers, 34(4-5); 2019: 331-345.
  11. Shaltooki M, Dini G, Mehdikhani M, Fabrication of chitosan-coated porous polycaprolactone/strontium-substituted bioactive glass nanocomposite scaffold for bone tissue engineering, Materials Science and Engineering C, 105; 2019:110138.
  12. Varshosaz J, Masoudi S, Mehdikhani M, Hashemi Beni B, Farsaei S, Atorvastatin lipid nanocapsules and gold nanoparticles embedded in injectable thermo-gelling hydrogel scaffold containing adipose tissue extracellular matrix for myocardial tissue regeneration, IET Nanobiotechnology, 2019 Dec;13(9):933-941. doi: 10.1049/iet-nbt.2019.0035.
  13. Haghighat A, Shakeri S, Mehdikhani M, Soltani Dehnavi S, Talebi A, Histological, Histomorphometric, and Osteogenesis Comparative Study of a Novel Fabricated Nanocomposite Membrane versus a Cytoplast Membrane, Journal of Oral and Maxillofacial Surgery, 77(10); 2019:2027-2039. https://doi.org/10.1016/j.joms.2019.05.012.
  14. Iron R, Mehdikhani M, Naghashzargar E, Karbasi S, Semnani D, Effects of nano-bioactive glass on structural, mechanical and bioactivity properties of Poly (3-hydroxybutyrate) electrospun scaffold for bone tissue engineering applications, Materials Technology: Advanced Performance Materials. 2019, 1-9. https://doi.org/10.1080/10667857.2019.1591728.
  15. Soltani Dehnavi S, Mehdikhani M, Rafienia M, Bonakdar Sh. Preparation and in vitro evaluation of polycaprolactone/PEG/bioactive glass nanopowders nanocomposite membranes for GTR/GBR applications, Materials Science & Engineering C. 2018; 90:236-247.
  16. Mehdikhani-Nahrkhalaji M, Tavakoli E, Zargar-Kharazi A, Hashemi-Beni B. A novel nano-composite scaffold for cartilage tissue engineering, Scientia Iranica, Transactions F: Nanotechnology. 2018; 25(3):1-9.
  17. Mehdikhani M, Ghaziof Sh. Electrically Conductive Poly--caprolactone/Polyethylene Glycol/Multi Wall Carbon Nanotubes Nanocomposite Scaffolds Coated with Fibrin Glue for Myocardial Tissue Engineering. Applied Physics A, Materials Science & Processing. 2018; 124:77:1-15.
  18. Soltani-Dehnavi Sh, Mehdikhani-Nahrkhalaji M, Rafienia M, Doostmohammadi A. Copper-doped and copper free bioactive glass nanopowders cytotoxicity and antibacterial activity assessment. Scientia Iranica, Transactions F: Nanotechnology. 2017; 24(3):1706-1716.
  19. Nazemi Z, Mehdikhani-Nahrkhalaji M, Haghbin-Nazarpak M, Staji H, Kalani MM. Antibacterial activity evaluation of bioactive glass and biphasic calcium phosphate nanopowders mixtures. Applied Physics A, Materials Science & Processing. 2016; 122(12), 1063:1-8.
  20. Nazemi Z, Haghbin-Nazarpak M, Mehdikhani-Nahrkhalaji M, Staji H, Kalani MM. Synthesis, characterization and antibacterial effects of sol-gel derived biphasic calcium phosphate nano powders. Micro & Nano letters. 2014; 9(6): 1-4.

21.  Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB, Hashemi-Beni B, Razavi SM, Novel poly (lactide-co-glycolide)/bioactive glass/hydroxyapatite nanocomposite coating for dental applications. Materials Science: Materials in Medicine. 2012; 23: 485-495 (2012).

22.  Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB, Razavi SM, Subcutaneous connective tissue reactions to the three types of bioactive glass nanopowders. Journal of Biomedical Nanotechnology. 2011; 7(3): 460-465.

23.  Mortazavi V, Mehdikhani-Nahrkhalaji M, Fathi MH, Mousavi SB, Nasr- Esfahani B, Antibacterial effects of sol-gel derived bioactive glass nanoparticle on aerobic bacteria. Journal of Biomedical Materials Research Part A. 2010; 94A: 160-168.

 

Selected Published ISC and other papers

1.     Falak M, Mehdikhani M, Varshosaz J, Hashemibeni, Ebrahimian-Hosseinabadi M, Fabrication and evaluation of spironolactone-loaded nanostructured lipid carries for cardiac tissue regeneration, 10 (4); 2020: 260-265.

2.     Haghighat A, Mehdikhani-Nahrkhalaji M, Reihani A, Soltani-Dehnavi Sh, Eblaghian G. Novel Chitosan/Polyethylene Glycol/Bioactive glass Nanocomposite membrane for Guided Tissue/Bone Regeneration. International Journal of Advanced Biotechnology and Research. 2017; 8(2): 787-800.

3.     Tavakoli E, Mehdikhani-Nahrkhalaji M, Sarafbidabad M. Poly (Lactic-co-Glycolic) Acid (PLGA)-Based Compounds for Articular Cartilage Regeneration. Journal of Reports in Pharmaceutical Sciences. 2016; 5(2): 94-103.

4.     Nazemi Z, Mehdikhani-Nahrkhalaji M, Haghbin Nazarpak M, Staji H. The antibacterial activity evaluation of sol-gel prepared Zn-doped biphasic calcium phosphate nanopowders. Advanced Science, Engineering and Medicine. 2015; 7: 995-1002.

5.     Mehdikhani-Nahrkhalaji M, Mohammad Hossein Fathi, Vajihesadat Mortazavi, Sayed Behrouz Mousavi, Ali Akhavan, Abbas Haghighat, Batool Hashemi-Beni, Sayed Mohammad Razavi, Fatemeh Mashadiabbas. Biocompatibility Evaluation of Biodegradable Nanocomposite coatings for dental and orthopaedic implant applications. Dental Research Journal. 2015; 12(1): 89-99.

6.     Mehdikhani-Nahrkhalaji M, Mohammad Hossein Fathi,Vajihesadat Mortazavi, Sayed Behrouz Mousavi, Batool Hashemi-Beni, Sayed Mohammad Razavi, Ali Akhavan, Abbas Haghighat. In Vivo and In Vitro Evaluation of Poly (lactide-co-glycolide)/Bioactive Glass Nanocomposite Coating. Advanced Materials Research. 2014; 829: 309-313.

7.     Parsapour A, Fathi MH, Salehi M, Saatchi A, Mehdikhani M.  The Effect of Surface Treatment on corrosion behavior of Surgical 316L Stainless Steel Implant. International Journal of Iron & Steel Society of Iran. 2007; 4(1,2): 34-38.

8.      

 

Selected Conferences and Proceedings

 

1.     Shahravi Z, Mehdikhani M, Amirkhani Mohammad Amir, Farsaei S, Molapour Sisakht Mahsa. Design of Novel Blend of Gellan Gum / Polyvinyl Alcohol as Nano-fibrous Scaffold for Wound Dressings with Appropriate Mechanical Properties, 4th International and 6th National Congress of Wound and Tissue Repair, 2019 November 19, Iranian Society of Dermatology, Razi Hall, Tehran, Iran.

2.     Mehdikhani M. New approaches to the tissue engineering. Symposium of application of Biotechnology in Medical Science, 2018 April 13, Royan Institute, Isfahan, Iran.

3.     Torabi H, Mehdikhani M. Injectable hydrogels for myocardial tissue regeneration. The First International Iranian Tissue Engineering and Regenerative Medicine Congress (ITERMC), 2018 July 18-20, Tehran, Iran.

 

4.     Ghaziof Sh,  Mehdikhani M. Renovaton of the injured myocardial tssue with new conductve, biodegradable,  and non-cytotoxic
polymer matrix coated with fbrin glue nanocomposite scaffold. Annual Biotechnology Congress, 2017 August 17-18, Toronto, Canada.

5.     Ghaziof  Sh, Mehdikhani-Nahrkhalaji M. New conductive nanocomposite scaffold coated with fibrin glue for myocardial tissue engineering, Global Congress on Tissue Engineering and Regenerative Medicine,2016 December 1-2, San Antonio, USA.

6.     Ghaziof  S, Mehdikhani-Nahrkhalaji M, Novel polycaprolactone/ Carbon nanotubes nanocomposite scaffold for cardiac tissue engineering, 5th International Conference on Tissue Engineering and Regenerative Medicine, 2016 September 12-14, Berlin, Germany.

7.     Mehdikhani-Nahrkhalaji M, Ghaziof  S. Preparation, Characterization, Mechanical, and Electrical Conductivity Assessment of Novel Polycaprolactone / Multi Wall Carbon Nanotubes Nanocomposites for Myocardial Tissue Engineering. 6th International Advances in Applied Physics and Materials Science Congress & Exhibition (APMAS2016), 2016 1-3 June, Steigenberger Hotel Maslak, Istanbul,Turkey.

8.     Sattari E, Hasanzadeh Nemati N, Mehdikhani-Nahrkhalaji M. Coating of mesoporous bioactive glass nanospheres on stainless steel 316Lby sol-gel method. The First International Conference on Science and Engineering, 2015, 1st of December, Dubai.

9.     Aghazadeh S, Hasanzadeh Nemati N, Mehdikhani-Nahrkhalaji M. Feassibility study on application of mesoporous bioactive glass nanospheres as a filler of cancerous bone defects. The First International Conference on Science and Engineering, 2015, 1st December, Dubai.

10.  Reihany A, Mehdikhani-Nahrkhalaji M, Haghighat A. Preparation and characterization of chitosan-45S bioactive glass nanocomposite membrane for guided tissue regeneration. 26th European Students ’ Conference, 2015, 23-26 September, Berlin, Germany.

11.  Aghazadeh S, Hasanzadeh Nemati N, Mehdikhani-Nahrkhalaji M. The effect of calcium oxide in bioactive glass composition on the preparation of spherical mesoporous nanoparticles for medical applications. The International Conference on New Research in chemistry and Chemical Engineering, 2015, 17 September, Tehran, Iran.  

12.  Tavakoli E, Mehdikhani-Nahrkhlaji M, Hashemi_beni B, Zargar-Kharazi A. Preparation, Characterization, and mechanical assessment of Poly (Lactic-co-Glycolic) Acid (PLGA) / Hyaluronic acid (Ha)/ Fibrin/ Bioactive glass Nano-composite scaffolds for cartilage tissue engineering applications. the 5th international conference on Ultrafine Grained and Nanostructured Materials, 2015, 11-12 November, Tehran, Iran.

13.  Khandan A,  Karamian E,  Mehdikhani-Nahrkhalaji M,  Mirmohammadi H, Farzadi A,  Ozada N,  Heidarshenas B,  Zamani K. Influence of Spark Plasma Sintering and Baghdadite Powder on Mechanical Properties of Hydroxyapatite. 5th international conference on Ultrafine Grained and Nanostructured Materials, 2015, 11-12 November, Tehran, Iran.

14.  Raziye I, Mehdikhani-Nahrkhalaji M, Karbasi S. Nanocomposites scaffold fabricated by electrospinning for bone tissue engineering. International Congress on Nanoscience & Nanotechnology 2014, 22-24 October, Tarbiat Modares University, Tehran,Iran.

15.  Nazemi Z, Mehdikhani-Nahrkhalaji M, Haghbin-Nazarpak M. Synthesis and characterization of Zn doped biphasic calcium phosphate nanoparticles prepared by sol-gel method. International Congress on Nanoscience & Nanotechnology, 2014, 22-24 October, Tarbiat Modares University, Tehran,Iran.

16.  Soltani-Dehnavi Sh, Mehdikhani-Nahrkhalaji M, Rafienia M, Doostmohammadi A. Antibacterial activity of sol-gel derived copper-incorporated and copper free bioactive glass nanoparticles on a gram-positive bacterium. 5th International Congress on Nanoscience & Nanotechnology, 2014, 22-24 October, Tarbiat Modares University, Tehran, Iran.

17.  Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V. In vivo and In Vitro evaluation of poly (lactide-co-glycolide)/bioactive glass nanocomposite coating in rabbit tibiae. 4th international conference on Ultrafine Grained and Nanostructured Materials, 2013, Tehran University, Tehran, Iran.

18.  Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Hashemi-Beni B. Poly (DL-lactide-co-glycolide)/ Bioactive glass nanocomposite coating for orthopedic and dental applications. Proceedings of the 4th International Conference on Nanostructures, 2012, 12-14 March, Kish Island, I.R. Iran.

19.  Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB, Hashemi-Beni B. Poly (DL-lactide-co-glycolide)/ Bioactive Glass/Hydroxyapatite   nanocomposite coating for dental implant applications. The 6nd Annual Meeting of the IADR Iranian Division, Session Title: Oral and Maxillofacial Surgery and Implantology, 2011, 29-30 December, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

20.  Mehdikhani Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB, Hashemi Beni B. Characterization and cytotoxicity evaluation of poly (DL-lactide-co- glycolide)/bioactive glass/hydroxyapatite nanocomposite coating on titanium, using human adipose derived mesenchymal stem cell. Proceedings of the 3rd Conference on Nanostructures, 2010, March 10-12, Kish Island, Iran. 

21.    Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB, Razavi SM. Subcutaneous connective tissue reactions to the three types of bioactive glass nanopowders. Diffusion in Solids and Liquids Conference, 2010, 5-7 July, Paris, France.

22.  Mortazavi V, Fathi MH, Mehdikhani Nahrkhalaji M. Antibacterial effects of bioactive glass nanopowders with different compositions. European Society for Artificial organs (ESAO), 2009, 2-5 September, Université de Technologie de Compiègne, , France, Sept 2-5, 2009.

23.  Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB. Preparation, characterization and bioactivity evaluation of bioactive glass nano-powders with three different compositions. New Materials National Congress, Materials and Energy Research Center, 2008, 10-12 June, Tehran, Iran.

 

 

Winning National Projects:

 

1.     Mehdi Mehdikhani (PI), Mohammad Rafienia, Shahin Bonakdar, Shiva Soltani-Dehnavi, Ali Doostmohammadi, Preparation and characterization of Polycaprolactone/Copper Doped Bioactive Glass Nanoparticles, The Office of President, Vice-Presidency for Science and Technology, Iran National Science Foundation, Start Date 06Apr2014 and End Date 16Dec2017.

2.     Mehdi Mehdikhani (PI), Anousheh Zargar Kharazi, Ebrahim Tavakoli, Fabrication, Characterization, and Evaluation of Bioactivity and Mechanical Properties of PLGA/FG/HA/nBG Nanocomposite Scaffold for Cartilage Tissue Engineering Application and Investigating the Attachment and Viability of Adipose Derived Mesenchymal Stem Cells on It, Start Date 04Apr2015 and End Date 19Dec2017.

 

 

 

Books:

 

1.     Pharmaceutics: Drug Delivery and Targeting, Perrie, Yvonne; Rades, Thomas, Second edition, Pharmaceutical Press, 2012, Translated by Mehdi Mehdikhani, Ebrahim Tavakoli, Bahjat Nafari, University of Isfahan Press.

 

 

 

 

 

 

 

 

 

 

 

 

 

The complete conference presentation list (http://eng.ui.ac.ir/~m.mehdikhani)

 

D. Additional Information: Courses


YEAR

COURSE TITLE

MAJOR

2011-

Biocompatibility

BME, M.Sc.

2012-

Physiology

BME, B.S, M.Sc.

2012-

 

Anatomy

BME, B.S, M.Sc.

2011-2014

Tissue engineering

BME, M.Sc.

2011-

Biological experiments and sterilization methods

 

BME, M.Sc.

2012-

Novel systems for delivery of biologic materials

BME, M.Sc.

2013-

Polymers and their applications in biomedical engineering

 

BME, M.Sc.

2011-

Ceramics and their applications in biomedical engineering

 

BME, M.Sc.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

2016-

Specialized English Language

BME, M.Sc.

BME: Biomedical Engineering

 

 

E. Additional Information: Distinguished Researcher

 

Item

Value

Web address

ORCID

0000-0002-6809-2891

https://orcid.org/0000-0002-6809-2891

Researcher ID

B-1421-2018

http://www.researcherid.com/rid/B-1421-2018

Scopus Author ID

36080960500

https://www.scopus.com/authid/detail.uri?authorId=36080960500

Google Scholar

Mehdi Mehdikhani

https://scholar.google.com/citations?user=KsaJoCUAAAAJ&hl=en

Researchgate

Mehdi Mehdikhani

https://www.researchgate.net/profile/Mehdi_Mehdikhani